The already huge interest in CBD products is expanding. Science and history have confirmed its many benefits. And only quality will distinguish the many brands entering the market. So, let’s look at what Leaf Labs from UK Meds could mean to you or those under your care.
There’s a science to this. Dr. Raphael Mechoulam, the Bulgarian-born Professor of Medicinal Chemistry at Jerusalem’s Hebrew University, has been making breakthrough discoveries since the 1960s. Among his findings is cannabis plants possess hundreds of cannabinoids that mesh with the human natural Endocannabinoid System (ECS). The ECS is an incredibly complex system threading throughout the brain and body including all its systems and glands. The best known and most effective of those cannabinoids are CBD (cannabidiol) and THC (∆9-tetrahydrocannabinol).
THC is a psychoactive agent that binds to CB1 and CB2 receptors in the Central Nervous System (CNS). In doing so, it can trigger mental effects from mild relaxation to creative focus to extreme paranoia. Governments have legislated against the possession and use of THC in cannabis sativa and Indica as a drug.
Hemp is botanically-related to cannabis. Hemp, however, contains little or no THC and its negative effects. This makes its dense CBD content legal and beneficial to thousands with scores of medical issues in the U.K.
CBD: the mechanism of action
CBD binds with CB1 and CB2 neurotransmitters. Where THC is an agonist, CBD’s chemistry is the opposite. It blocks the interference or intervention of compounds targeting those receptors. And it effectively offsets any influence of THC to help stabilize the flow of neural messages.
CBD runs interference on enzymes that degrade anandamide. Anandamide is a fatty acid amide hydrolase (FAAH) scientists believe is the source of feelings of calm and bliss. The body absorbs anandamide routinely, but stress and pain accelerate the absorption leaving the system imbalanced. But CBD modulates that absorption to manage good moods.
CBD also contributes to an “entourage effect” generating more impact as benefits ride its coattails. That is, while you can trace CBD’s mechanism of action to a certain extent, it appears to carry side benefits not so easily explained.
CBD: the science studies
Thousands of researches are working on the nature and effects of CBD. But many specifically address known and common physical and psychological conditions. A selected few support its efficacy:
- Spasticity: Parents have long administered CBD Oil to children afflicted by epilepsy. A 2017 study published in The Journal of Epilepsy Research concluded, “These are exciting times for research in cannabinoids. After almost four millennia of their documented medical use in the treatment of seizure disorders, we are very close to obtaining conclusive evidence of their efficacy in some severe epilepsy syndromes.” Clearly, the purity of the CBD Oil is vital to any pediatric therapy for recalcitrant epilepsy.
Additional research focuses on CBD’s beneficial effect on spasticity related to Muscular Dystrophy, Cerebral Dystrophy, and Multiple Sclerosis. And, some people report benefits for treating muscular pain and cramps linked to Fibromyalgia, Premenstrual Syndrome, Restless Leg Syndrome, and too much physical exercise.
- Inflammation: Various causes trigger inflammation in muscles, joints, nerves, and body tissue. White blood cells gather at the point of injury to protect it from additional damage. In autoimmune disease, including arthritis, Cystic Fibrosis, diabetic neuropathy, fibromyalgia, lupus, and more, the protective response occurs only to aggravate the problem even when there has been no injury.
The consequent swelling produces mild to severe chronic pain. Free Radical Biology & Medicine covered a 2011 study reviewing effects of cannabinoids on the oxidation that contributes to inflammation showing the “non-psychotropic cannabinoid cannabidiol, which may interact with the endocannabinoid system but has actions that are distinct, offers promise as a prototype for anti-inflammatory drug development.” That promise also may extend to atherosclerosis, Alzheimer’s disease, hypertension, and depression.
- Anxiety: CBD has anxiolytic benefits affecting the limbic and paralimbic brain. Administered in oil, capsules, or vaping, CBD modulates blood flow, neural transmission, and nerve sheathing to balance hippocampus rhythms. Research in 2014 in CNS & Neurological Disorders Drug Targets asserted, “Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound.”
How CBD produces the calm, rest, and remedy for insomnia remains unclear. But, anecdotal history of its benefit dates back millennia.
There is more science of course on more benefits. Unfortunately, some governance of research has limited studies on animal subjects and restricted long-term human studies.
CBD: oil, capsules, or vape
How you use CBD is pretty much at your discretion. But CBD oil, capsules, and vape offer options to health-damaging smoking. Each of these methods offers convenience and discrete consumption. But you want to use the best available.
- CBD Oil: Consumers and caregivers administer CBD Oil sublingually which speeds its process and effect as sensitive oral tissues absorb its values. Through Leaf Labs, you can order dosages at 250mg/bottle, 500mg/bottle, or 1,000mg/bottle and in natural, peppermint, or citrus flavors. It’s offered with the same patient precautions as the capsules, but because it works faster, you should pay attention to its potential to make you drowsy.
- CBD Capsules: CBD capsules provide a measured serving of CBD oil in a small tasteless pill. Authorized by the MHRA, Leaf Labs’ CBD capsules come 30 capsules to a bottle for a dose of 10mg/capsule. They recommend building dosage after assessing the effects. It is also smart to confer with your doctor regarding interaction with other prescriptions and consumption of grapefruit.
- CBD Vape Oil: Vaping inhales the vapors of CBD Oil in the vaper’s cartridge. Vaping helps those who are weaning their way off cigarettes as it continues to satisfy the user’s oral fixation. You can even add it to nicotine-infused vape oils. To remain legal in the U.K., the CBD must contain only trace amounts of THC, even below 0.2%. Leaf Labs’ pure-tested vape oil comes in 250mg/bottle and 500mg/bottle doses. They offer the same precautions for use.
Leaf Labs’ is Nottingham-based, the U.K.’s fastest-growing online distributor of high-quality products including CBD Oil, Capsules, and Vape Oil. And, their website helps you select a product, secure any required consultation and buy CBD from UK Meds.